Polymer-Supported Synthesis of α- and β-Hydroxyketones through the Formation of 1,3-Dithiane Intermediates

Abstract

The synthesis of polymer-supported 2-monosubstituted 1,3-dithianes from soluble copolymers bearing 1,3-propanedithiol groups, their lithiation, reactions with electrophiles such as aldehydes, ketones, α,β-unsaturated ketones and oxiranes, and cleavage of the produced dithioketal-protected α- or β-hydroxyketones with various reagents have been studied.

solid-phase synthesis - polymeric dithiols - polymeric dithianes - lithiation - umpolung

References and Notes

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3-Benzoyl-2-cyclohexen-1-ol (8ah)
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